HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1872373Generated: November 1, 2026
Acetic Acid → 5-hydroxybenzo[b]thiophene-2-carboxylic acid
https://huagongshe.com/reaction/1872373
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | HCID 21182275 | HCID 21182275 | — |
| Product | 5-hydroxybenzo[b]thiophene-2-carboxylic acid | HCID 268651 | — |
Reaction Steps
A mixture of 2-Carbamoyl-5-methoxybenzo[b]thiophene (2.0 g), acetic acid (5 ml) and 48% hydrobromic acid (20 ml) was stirred for 16 hours at 110° C., and the mixture was poured into the ice-water. The resulting precipitate was collected by filtration, and dried to give 5-Hydroxybenzo[b]thiophene-2-carboxylic acid (1.66 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06107458 |
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| Source dataset | uspto-grants-2000_08 |
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| ORD ID | ord-9368ac8bb7f243bbb943db3cb24b76cf |
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| Source note | uspto-grants-2000_08 |
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