HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → (cis-4,5-Diphenyl-4,5-dihydro-1H-imidazol-2-yl)amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | cis-4,5-Diphenyl-2-methylthio-4,5-dihydro-imidazole-1-carboxylic Acid, Tert-Butyl Ester | HCID 86596320 | — |
| Solvent | Ethylene Glycol | HCID 174 | — |
| Product | (cis-4,5-Diphenyl-4,5-dihydro-1H-imidazol-2-yl)amine | HCID 59655468 | — |
Reaction Conditions
| Temperature | 115 °C |
|---|
Reaction Steps
A solution of intermediate 59 (1.0 g, 2.71 mmol) in ethylene glycol (10 mL) is saturated with ammonia and is heated in a pressure tube at 115° C. for 3 h. The reaction mixture is cooled to rt, and saturated with ammonia, and heated is heated at 115° C. overnight. The reaction mixture is cooled to rt, and the product is precipitated by the addition of addition of water to give 226 mg of the product 122. 1H NMR (DMSO-d6) δ 7.10-6.80 (m, 10 H), 6.40 (bs, 3 H), 5.10 (s, 2 H); LC/MS: 2.89 min, m/z 238 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07741493B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-2d62f557fbb243ceaea737eaf4f4f398 |
| Source note | uspto-grants-2010_06 |