HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Cyanopyridine → 3,4-Dihydro-4-oxo-2-(pyridin-3-yl)-6-methylthieno[2,3-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Cyanopyridine | HCID 79 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl 2-Amino-5-methylthiophene-3-carboxylate | HCID 4062885 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3,4-Dihydro-4-oxo-2-(pyridin-3-yl)-6-methylthieno[2,3-d]pyrimidine | HCID 23287906 | 95.1% |
Reaction Steps
5 g of 2-amino-5-methyl-3-ethoxycarbonylthiophene together with 2.7 g of 3-cyanopyridine are dissolved in 40 ml of dioxane. Then, gaseous HCl is passed through the solution for 5 hours. After customary workup, 6 g of 3,4-dihydro-4-oxo-2-(pyridin-3-yl)-6-methylthieno[2,3-d]pyrimidine are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06110920 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-1ee565c856da4d75ba90f1cced5233ce |
| Source note | uspto-grants-2000_08 |