1-(2-Hydroxyethyl)piperazine → HCID 18408714, compound

HRID 1872569Notes

Reaction equation

HRID 1872569 reaction equation
[C:1]([Si:5]([CH3:24])([CH3:23])[O:6][C:7]1[CH:8]=[C:9]([C:13]2(Br)[C:18](=[O:19])[NH:17][C:16](=[O:20])[NH:15][C:14]2=[O:21])[CH:10]=[CH:11][CH:12]=1)([CH3:4])([CH3:3])[CH3:2].[OH:25][CH2:26][CH2:27][N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>CO>[OH:25][CH2:26][CH2:27][N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH:29]1[C:13]1([C:9]2[CH:10]=[CH:11][CH:12]=[C:7]([O:6][Si:5]([C:1]([CH3:4])([CH3:3])[CH3:2])([CH3:24])[CH3:23])[CH:8]=2)[C:18](=[O:19])[NH:17][C:16](=[O:20])[NH:15][C:14]1=[O:21]

Participants

4

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 18408764HCID 18408764, compound

Product 1

HCID 18408714HCID 18408714, compoundYield 14.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 5-[3-(tertbutyldimethylsilyloxy)phenyl]-5-bromobarbituric acid (444 mg) and N-(2-hydroxyethyl)piperazine (420 mg) in 10 ml of methanol is stirred at room temperature for 5 hours, then the solvent is evaporated off and the residue is purified by silica gel chromatography (13 g; eluent: ethyl acetate/methanol 3:1), to give 70 mg of the product.

Workup

  1. customthe solvent is evaporated off
  2. customthe residue is purified by silica gel chromatography (13 g; eluent: ethyl acetate/methanol 3:1)

Sources & evidence

ORD record
ord-a3f38857e0a3471bb433d4af1922bccb
Source dataset
uspto-grants-2000_08
Patent number
US06110924

Reaction notes

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