Acetic Acid → HCID 54170807, compound

Participants

Reaction Steps

To a solution of 5-[N-(2-hydroxyethyl)piperazinyl]-5-[3-(tertbutyldimethylsilyloxy)phenyl]barbituric acid (170 mg) in 12 ml of tetrahydrofuran, kept at 0° C. and under nitrogen atmosphere, are added 333 μl of acetic acid and 0.69 ml of tetrabutylammonium fluoride. The mixture is stirred for 3 hours then the solvent is evaporated off and the residue is purified by silica gel chromatography (15 g; eluent: ethyl acetate/methanol 4:1), to give, after crystallization from methanol, 35 mg of the product, m.p. 219-221° C.

Provenance & Evidence