反应详情

To a solution of 5-bromo-5-octylbarbituric acid (23.52 g) in 70 ml of dimethylsulfoxide, kept under nitrogen atmosphere and at a temperature of 5-10° C., is dropped N-(2-hydroxyethyl)piperazine (36.2 ml), then the mixture is stirred at room temperature for 2 hours 30 minutes. The reaction mixture is poured into water (1 l) under stirring and cooling with an ice bath. The white solid which separates is recovered by filtration washed with water and dried under vacuum at 40° C., to give, after crystallization from ethanol (140 ml) 10.91 g of the product as a white solid, m.p. 183-184° C.

1. customkept under nitrogen atmosphere and at a temperature of 5-10° C.
2. stirringunder stirring
3. temperaturecooling with an ice bath
4. filtrationThe white solid which separates is recovered by filtration
5. washwashed with water
6. customdried under vacuum at 40° C.
7. customto give
8. customafter crystallization from ethanol (140 ml) 10.91 g of the product as a white solid, m.p. 183-184° C.