HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzaldehyde → (2-Bromophenyl)[2-chloro-4-(E-((4-acetylhomopiperazin-1-yl)carbonyl) ethenyl)phenyl]sulfide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzaldehyde | HCID 6996 | — |
| Reactant | 6-Amino-1-hexanol | HCID 19960 | — |
| Reactant | 2,4-Dichlorobenzenethiol | HCID 70730 | — |
| Reactant | 2-Bromobenzenethiol | HCID 80598 | — |
| Reactant | N-Acetylhomopiperazine | HCID 4186202 | — |
| Product | (2-Bromophenyl)[2-chloro-4-(E-((4-acetylhomopiperazin-1-yl)carbonyl) ethenyl)phenyl]sulfide | HCID 9805756 | — |
Reaction Steps
The title compound was prepared by the procedures described in Example 1 substituting 2,4-dichlorothiophenol with 2-bromothiophenol, 2-chlorobenzaldehyde with 3-chloro-4-fluoro-benzadehyde, and 6-amino-1-hexanol with 4-acetylhomopiperazine. 1H NMR (DMSO-d6, 300 MHz) δ 8.10 (m, 1H), 7.81 (d, J=7.7 Hz, 1H), 7.64 (m, 1H), 7.24-7.51 (m, 5H), 7.05 (m, 1H), 3.39-3.77 (m, 8H), 1.97 (m, 3H), 1.68 (m, 2H). HRMS calculated for C22H22N2O2S1Br1Cl1 : 493.0352. Observed: 493.0352.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06110922 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-842c52242269492eaf35edea5453cb0f |
| Source note | uspto-grants-2000_08 |