HCID 18687463, compound → HCID 54490032, compound

HRID 1872690Notes

Reaction equation

HRID 1872690 reaction equation
[Si:1]([O:8][CH2:9][C:10]1[CH:11]=[C:12]([C:18]2([C:21]([F:24])([F:23])[F:22])[NH:20][NH:19]2)[CH:13]=[CH:14][C:15]=1[O:16][CH3:17])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]>CCOCC>[Si:1]([O:8][CH2:9][C:10]1[CH:11]=[C:12]([C:18]2([C:21]([F:22])([F:23])[F:24])[N:19]=[N:20]2)[CH:13]=[CH:14][C:15]=1[O:16][CH3:17])([C:4]([CH3:7])([CH3:5])[CH3:6])([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 18687463HCID 18687463, compound

Product 1

HCID 54490032HCID 54490032, compoundYield 94.3%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 3-[3-(tert-butyldimethylsilanyloxymethyl)-4-methoxyphenyl]-3-trifluoromethyldiaziridine (200 mg, 0.55 mmol) and freshly prepared Ag2O(255 mg, 1.1 mmol) in ether (3 ml) was stirred for 24 h. The solid was filtered, washed with ether, and the filtrate evaporated in vacuo. The resulting residue was purified by chromatography (SiO2, 10% ether/petrol) to give the title compound (187 mg, 94%) as a colourless oil.

Workup

  1. filtrationThe solid was filtered
  2. washwashed with ether
  3. customthe filtrate evaporated in vacuo
  4. customThe resulting residue was purified by chromatography (SiO2, 10% ether/petrol)

Sources & evidence

ORD record
ord-60b983f7da5344e8b62cafefd0ed196f
Source dataset
uspto-grants-2000_08
Patent number
US06110934

Reaction notes

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