反应详情

A solution of 5-aminoisoquinoline (10 g, 69 mmol) in glacial acetic acid (150 ml) and concentrated sulfuric acid (1 ml) was hydrogenated over platinum oxide (1 g) at 55 psi for 20h. The acetic acid was then removed in vacuo and the residue treated with saturated aqueous potassium carbonate (100 ml) and extracted with dichloromethane. The organic layer was dried over sodium sulfate and concentrated in vacuo to afford the title compound (6.45 g).

1. customThe acetic acid was then removed in vacuo
2. additionthe residue treated with saturated aqueous potassium carbonate (100 ml)
3. extractionextracted with dichloromethane
4. dry with materialThe organic layer was dried over sodium sulfate
5. concentrationconcentrated in vacuo