HCID 13338332, compound → HCID 18687355, compound

Participants

Reaction Steps

9-Amino-6-chloro-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, prepared according to R. M. DeMarinis et al, J. Med. Chem., 1984, 27, 918, (0.190 g, 0.90 mmol) was dissolved in 10% acetic acid in methanol (50 ml) and 10% Pd/C (150 mg) added. The mixture was stirred at room temperature, under hydrogen/atmos pressure for 4h, then filtered through Kieselguhr and evaporated in vacuo. Residual material was taken up into dichloromethane and 5% NaHCO3 solution; the organic layer was washed with brine, dried (Na2SO4) and evaporated in vacuo to afford the title compound as a colourless oil (133 mg).

Provenance & Evidence