2-Methyl-1,2,3,4-tetrahydroisoquinolin-5-amine → N-(2-Methyl-1,2,3,4-tetrahydroisoquinol-5-yl)-4-azido-5-iodo-2-methoxybenzamide

HRID 1872716Notes

Reaction equation

HRID 1872716 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH3:12])[CH2:7]2.[N:13]([C:16]1[C:24]([I:25])=[CH:23][C:19]([C:20](O)=[O:21])=[C:18]([O:26][CH3:27])[CH:17]=1)=[N+:14]=[N-:15]>>[CH3:12][N:6]1[CH2:5][CH2:4][C:3]2[C:8](=[CH:9][CH:10]=[CH:11][C:2]=2[NH:1][C:20](=[O:21])[C:19]2[CH:23]=[C:24]([I:25])[C:16]([N:13]=[N+:14]=[N-:15])=[CH:17][C:18]=2[O:26][CH3:27])[CH2:7]1

Participants

3

Reactant 2

HCID 141712692-Methyl-1,2,3,4-tetrahydroisoquinolin-5-amineHCID 186873664-Azido-5-iodo-2-methoxybenzoic acid

Product 1

HCID 18687454N-(2-Methyl-1,2,3,4-tetrahydroisoquinol-5-yl)-4-azido-5-iodo-2-methoxybenzamide

Procedure

The title compound was prepared in an analogous manner to Example 1 from 5-amino-2-methyl-1,2,3,4-tetrahydroisoquinoline and 4-azido-5-iodo-2-methoxybenzoic acid.

Sources & evidence

ORD record
ord-9a5f157378eb499e837afb8a19c3ad56
Source dataset
uspto-grants-2000_08
Patent number
US06110934

Reaction notes

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