2-Methyl-1,2,3,4-tetrahydroisoquinolin-5-amine → HCID 18687455, compound

HRID 1872717Notes

Reaction equation

HRID 1872717 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH3:12])[CH2:7]2.[C:13]([NH:16][C:17]1[C:25]([Cl:26])=[CH:24][C:20]([C:21](O)=[O:22])=[C:19]([O:27][CH2:28][CH2:29][CH3:30])[CH:18]=1)(=[O:15])[CH3:14]>>[CH3:12][N:6]1[CH2:5][CH2:4][C:3]2[C:8](=[CH:9][CH:10]=[CH:11][C:2]=2[NH:1][C:21](=[O:22])[C:20]2[CH:24]=[C:25]([Cl:26])[C:17]([NH:16][C:13](=[O:15])[CH3:14])=[CH:18][C:19]=2[O:27][CH2:28][CH2:29][CH3:30])[CH2:7]1

Participants

3

Reactant 2

HCID 141712692-Methyl-1,2,3,4-tetrahydroisoquinolin-5-amineHCID 18687348HCID 18687348, compound

Product 1

HCID 18687455HCID 18687455, compound

Procedure

The title compound was prepared in an analogous manner to Example 1 from 5-amino-2-methyl-1,2,3,4-tetrahydroisoquinoline and 4-acetylamino-5-chloro-2-propoxybenzoic acid.

Sources & evidence

ORD record
ord-8cb12eaa754645388aaa052db1fc4845
Source dataset
uspto-grants-2000_08
Patent number
US06110934

Reaction notes

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