2-Methyl-1,2,3,4-tetrahydroisoquinolin-5-amine → HCID 18687375, compound

HRID 1872724Notes

Reaction equation

HRID 1872724 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH3:12])[CH2:7]2.[F:13][C:14]([F:30])([F:29])[C:15]1([C:18]2[CH:19]=[CH:20][C:21]([O:27][CH3:28])=[C:22]([CH:26]=2)[C:23](O)=[O:24])[N:17]=[N:16]1>>[CH3:12][N:6]1[CH2:5][CH2:4][C:3]2[C:8](=[CH:9][CH:10]=[CH:11][C:2]=2[NH:1][C:23](=[O:24])[C:22]2[CH:26]=[C:18]([C:15]3([C:14]([F:30])([F:13])[F:29])[N:17]=[N:16]3)[CH:19]=[CH:20][C:21]=2[O:27][CH3:28])[CH2:7]1

Participants

3

Reactant 2

HCID 141712692-Methyl-1,2,3,4-tetrahydroisoquinolin-5-amineHCID 18687430HCID 18687430, compound

Product 1

HCID 18687375HCID 18687375, compound

Procedure

The title compound was prepared in an analogous manner to Example 1 from 5-amino-2-methyl-1,2,3,4-tetrahydroisoquinoline and 5-[3-(trifluoromethyl)-3H-diazirin-3-yl]-2-methoxybenzoic acid.

Sources & evidence

ORD record
ord-693739c414c64d459048efe9528bf20b
Source dataset
uspto-grants-2000_08
Patent number
US06110934

Reaction notes

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