5-(N,N-dimethylsulfamoyl)-2-methoxybenzoic acid → N-(2-Methyl-1,2,3,4-tetrahydroisoquinolin-5-yl)-5-dimethylsulfamoyl-2-methoxybenzamide

HRID 1872731Notes

Reaction equation

HRID 1872731 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH3:12])[CH2:7]2.[CH3:13][N:14]([CH3:29])[S:15]([C:18]1[CH:19]=[CH:20][C:21]([O:27][CH3:28])=[C:22]([CH:26]=1)[C:23](O)=[O:24])(=[O:17])=[O:16]>>[CH3:12][N:6]1[CH2:5][CH2:4][C:3]2[C:8](=[CH:9][CH:10]=[CH:11][C:2]=2[NH:1][C:23](=[O:24])[C:22]2[CH:26]=[C:18]([S:15](=[O:17])(=[O:16])[N:14]([CH3:29])[CH3:13])[CH:19]=[CH:20][C:21]=2[O:27][CH3:28])[CH2:7]1

Participants

3

Reactant 2

HCID 135768955-(N,N-dimethylsulfamoyl)-2-methoxybenzoic acidHCID 141712692-Methyl-1,2,3,4-tetrahydroisoquinolin-5-amine

Product 1

HCID 18687402N-(2-Methyl-1,2,3,4-tetrahydroisoquinolin-5-yl)-5-dimethylsulfamoyl-2-methoxybenzamide

Procedure

The title compound was prepared in an analogous manner to Example 1 from 5-amino-2-methyl-1,2,3,4-tetrahydroisoquinoline and 5-dimethylsulfamoyl-2-methoxybenzoic acid.

Sources & evidence

ORD record
ord-cf7960b0862f48e7a53c1f1dc20b3d74
Source dataset
uspto-grants-2000_08
Patent number
US06110934

Reaction notes

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