Hydrogen Bromide → Eletriptan Hydrobromide

Participants

Reaction Conditions

Reaction Steps

62% w/w Hydrobromic acid (1.706 g, 13.07 mmol) was added over 1 hour to a stirred solution of 3-(N-methyl-2(R)-pyrrolidinylmethyl)-5-(2-phenylsulphonylethyl)-1H-indole (5.0 g, 13.07 mmol) in acetone (112 ml) at 0-5° C. After slurrying of the reaction mixture at 0-5° C. for 3 hours, heating under reflux for 2 hours was effected followed by cooling to 0-5° C. and further slurrying for 1 hour at this temperature. Filtration, followed by washing with acetone and drying in vacuo, furnished the title compound (5.18 g), which was identical to that of Example 1.

Provenance & Evidence