HCID 18687527, compound → HCID 3698157, compound

Participants

Reaction Steps

A mixture of (±)-1,1-dimethylethyl 7-(hydroxyphenylmethyl)-1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylate (183.6 g) and potassium tert-butoxide (6 g) in toluene (900 ml) was stirred and refluxed for 2 hours. The solvent was evaporated and the residue was stirred in petrol ether and water. The mixture was decanted and the residue was stirred up in DIPE. The precipitate was filtered off and dried, yielding 127.4 g (92%) of (±)-tetrahydro-1'-phenylspiro(1,3-dioxolan-2,7'(8'H)-3H-oxazolo[3,4-a]pyridin)-3'-one (interm. 2).

Provenance & Evidence