HCID 86755695, compound → HCID 86755694, compound

Participants

Reaction Steps

A mixture of (±)-cis-N-[1,2-bis(phenylmethyl)-4-piperidinyl]-1-methyl-1H-benzimidazol-2-amine (4.7 g) in methanol (200 ml) was hydrogenated with palladium on activated carbon (10%; 2 g) as a catalyst. After uptake of hydrogen, the catalyst was filtered off and the filtrate was evaporated. The residue was purified by column chromatography over silica gel (eluent: CH2Cl2 /CH3OH 95/5). The pure fractions were collected and the solvent evaporated. The residue was suspended in DIPE, filtered and dried, yielding 0.6 g (17%) of (±)-cis-1-methyl-N-[2-(phenylmethyl)-4-piperidinyl]-1H-benzimidazol-2-amine (interm. 31; mp. 86.3° C.).

Provenance & Evidence