Ethylenediamine → HCID 15480135, compound

HRID 1872779Notes

Reaction equation

HRID 1872779 reaction equation
[N:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:11][CH:10]=[N:9][C:8]=2[C:12]=1[CH3:13])=[C:2]=[S:3].[CH2:14]([NH2:17])[CH2:15][NH2:16]>C1(C)C=CC=CC=1>[NH2:16][CH2:15][CH2:14][NH:17][C:2](=[S:3])[NH:1][C:4]1[CH:5]=[CH:6][C:7]2[O:11][CH:10]=[N:9][C:8]=2[C:12]=1[CH3:13]

Participants

4

Reactant 2

HCID 3301EthylenediamineHCID 15480134HCID 15480134, compound

Product 1

HCID 15480135HCID 15480135, compoundYield 94.9%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 5-isothiocyanato-4-methylbenzoxazole (0.68 g, 3.58 mmol) in toluene (75 mL) is treated with ethylenediamine (0.84 mL, 12.53 mmol). The reaction is stirred for 30 minutes as the product precipitates. The precipitate is filtered and dried in an oven to yield 0.85 g of 5-[N'-(2-aminoethyl)thioureido]-4-methylbenzoxazole as a white solid.

Workup

  1. customprecipitates
  2. filtrationThe precipitate is filtered
  3. customdried in an oven

Sources & evidence

ORD record
ord-87052116ffe24348a147f99a9c2f2a08
Source dataset
uspto-grants-2000_08
Patent number
US06110952

Reaction notes

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