Ethylenediamine → 5-[N'-(2-aminoethyl)thioureido]-4-ethylbenzoxazole

HRID 1872787Notes

Reaction equation

HRID 1872787 reaction equation
[CH2:1]([C:3]1[C:8]2[N:9]=[CH:10][O:11][C:7]=2[CH:6]=[CH:5][C:4]=1[N:12]=[C:13]=[S:14])[CH3:2].[CH2:15]([NH2:18])[CH2:16][NH2:17]>C1(C)C=CC=CC=1>[NH2:17][CH2:16][CH2:15][NH:18][C:13](=[S:14])[NH:12][C:4]1[CH:5]=[CH:6][C:7]2[O:11][CH:10]=[N:9][C:8]=2[C:3]=1[CH2:1][CH3:2]

Participants

4

Reactant 2

HCID 3301EthylenediamineHCID 154801434-Ethyl-5-isothiocyanatobenzoxazole

Product 1

HCID 154801445-[N'-(2-aminoethyl)thioureido]-4-ethylbenzoxazole

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 4-ethyl-5-isothiocyanatobenzoxazole (3.58 mmol) in toluene (75 mL) is treated with ethylenediamine (12.53 mmol). The reaction is stirred for 30 minutes as the product precipitates. The precipitate is filtered and dried in an oven to yield 5-[N'-(2-aminoethyl)thioureido]-4-ethylbenzoxazole as a white solid.

Workup

  1. customprecipitates
  2. filtrationThe precipitate is filtered
  3. customdried in an oven

Sources & evidence

ORD record
ord-c3cab48dd3a342bbbba4776b80995e15
Source dataset
uspto-grants-2000_08
Patent number
US06110952

Reaction notes

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