Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1872833Generated: October 25, 2026

4-(5-Fluoro-1H-indol-3-YL)cyclohexanone → 3-(4-oxocyclohexyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/1872833

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(5-Fluoro-1H-indol-3-YL)cyclohexanoneHCID 10704683—
Reactant3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-cyano-1H-indoleHCID 15521973—
Product3-(4-oxocyclohexyl)-1H-indole-5-carbonitrileHCID 11241886—

Reaction Steps

This compound was prepared in the manner as described above for (3a) by replacing 4-(5-fluoro-1H-3-indolyl)-cyclohexanone ethylene ketal with 4-(5-cyano-1H-3-indolyl)-cyclohexanone ethylene ketal (6 g) in 81% (4.0 g) of product as a white solid: mp 162.5-164° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06110956
Source datasetuspto-grants-2000_08
ORD IDord-2d2af9a4a22843a7bbacec252f6804c3
Source noteuspto-grants-2000_08