反应详情

A mixture of 4-(5-cyano-1-methyl-3-indolyl)-cyclohex-3-en-isomer ethylene ketal (3.77 g) and 10% palladium on carbon (0.99 g) in ethanol-tetrahydrofuran (200:80 ml) was hydrogenated for 5 hours. The catalyst was filtered off and the solvent was removed under vacuum to afford a white powder which was washed with ethanol-hexanes (1:1) and dried under vacuum for 4 hours (2.75 g): mp 170-172° C.

1. filtrationThe catalyst was filtered off
2. customthe solvent was removed under vacuum
3. customto afford a white powder which
4. washwas washed with ethanol-hexanes (1:1)
5. customdried under vacuum for 4 hours (2.75 g)