Water → HCID 18687685, compound

Participants

Reaction Steps

A solution of 2-(2-methoxy-4,5-difluoro-phenoxy)-ethylazide (0.69 g, 3.46 mmol) and triphenylphosphine (1.27 g, 4.84 mmol) in tetrahydrofuran (15 ml) containing water (0.08 ml) was stirred at room temperature overnight. The solvent was removed under vacuum. Chromatography with ethyl acetate removed triphenylphosphine oxide, followed elution with ethyl acetate-methanol-ammonium hydroxide 8.5:1.5:0.5, afforded 0.53 g of product as a white solid: mp 44-46° C.; MS EI m/e 203 (M+).

Provenance & Evidence