Hydrochloric Acid → HCID 18687695, compound

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Reaction Steps

To a solution of 1-(8-tert-butyl-2,3-dihydrobenzopyran-6-yl)-3-methyl-2-buten-1-one (0.62 g, 2.26 mmol) in Et2O (10 mL) is bubbled hydrogen chloride gas for about 15 min. The resulting solution is stirred at room temperature for 1 h, and concentrated. The resulting off-white oil is purified by flash column chromatography on silica (hexanes, hexanes/EtOAc; 10/1) to give the title compound (0.425 g. 61 %) as a pale yellow oil.

Provenance & Evidence