Leflunomide → 4-(Trifluoromethyl)aniline

HRID 187304Notes

Reaction equation

HRID 187304 reaction equation
[CH3:1][c:2]1[c:3]([C:4](=[O:5])[NH:9][c:10]2[cH:11][cH:12][c:13]([C:16]([F:17])([F:18])[F:19])[cH:14][cH:15]2)[cH:6][n:7][o:8]1.[CH3:20][c:21]1[c:22]([C:26](=[O:27])[OH:28])[cH:23][n:24][o:25]1>>[CH3:20][c:21]1[c:22]([C:26](=[O:27])[OH:28])[cH:23][n:24][o:25]1.[NH2:9][c:10]1[cH:11][cH:12][c:13]([C:16]([F:17])([F:18])[F:19])[cH:14][cH:15]1

Participants

4

Reactant 2

HCID 3899LeflunomideHCID 14252405-Methylisoxazole-4-carboxylic acid

Product 2

HCID 99644-(Trifluoromethyl)anilineHCID 14252405-Methylisoxazole-4-carboxylic acid

Sources & evidence

ORD record
ord-702d5bfa95df4062a9b7221cdbe3ba86
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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