Bromine → HCID 86755709, compound

Participants

Reaction Steps

Prepared from 2,6-dibromo-4-(6-methoxy-benzo[b]naphtho[2,3-d]thiophen-11-yl )-phenol (Example 63) and (S)-2-hydroxy-3-phenylpropionic acid, methyl ester (Example 96) according to the procedure of Example 107. White solid (0.608 g, 96%): NMR (THF-d8); δ8.29-8.26 (m, 1 H), 7.87 (d., J=8 Hz, 1 H), 7.72 - 7.68 (dd, 2 H, J=4, 2 Hz), 7.60 - 7.56 (m, 2 H), 7.48-7.37 (m, 4 H), 7.32 - 7.28 (m, 2 H), 7.25-7.23 (m, 2 H), 7.20 - 7.15 (m, 2 H), 6.85 - 6.82 (m, 1 H), 5.22(dd, 1 H, J=14, 2, Hz), 4.17 (s, 1 H), 3.71 (s, 1 H), 3.58(s, 6 H), ; MS (FAB+): [M+], 2 bromine isotope pattern, 674 (40%), 676 (66%), 678 (45%); Anal. Calc. for C33H24Br2O4S: C, 58.60, H, 3.58, N, 0.00. Found: C, 58.11, H, 3.53, N, 0.19.

Provenance & Evidence