Bromine → (R)-2-[2,6-Dibromo-4-(6-bromo-benzo[b]naphtho[2,3-d]thiophen-11-yl)-phenoxy]-propionic acid

참여 물질

역할	이름	HCID	투입량
반응물	Bromine	HCID 24408	—
반응물	methyl (S)-lactate	HCID 94386	—
반응물	2,6-Dibromo-4-(6-bromo-benzo[b]naphtho[2,3-d]thiophen-11-yl)-phenol	HCID 10840654	—
생성물	(R)-2-[2,6-Dibromo-4-(6-bromo-benzo[b]naphtho[2,3-d]thiophen-11-yl)-phenoxy]-propionic acid	HCID 9809490	—

반응 단계

Prepared from of 2,6-dibromo-4-(6-bromo-benzo[b]naphtho[2,3-d]thiophen-11-yl)-phenol (Example 21) and commercially available (S)-lactic acid, methyl ester. White solid: mp 131-133 ° C.: NMR (CDCl3);δ8.37 (d, J=9 Hz, 1 H), 7.84 (d, J=8 Hz, 1 H), 7.71-7.65 (m, 3 H), 7.57-7.50(m, 2 H), 7.45 (ddd, J=8, 7, 1 Hz, 1 H), 7.18 (ddd, J=8,7, 1 Hz, 1 H), 6.73 (d, J=8 Hz, 1 H), 5.36 (q, J=7 Hz, 1 H), 1.82 (d, J=7 Hz, 3 H); MS (EI): [M-H]+, 3 bromine isotope pattern, 631 (14%), 633 (44 %), 635 (42%), 637 (16%); Anal. Calc. for C25H15Br3O3S: C, 47.27, H, 2.38, N, 0.00. Found: C, 47.57, H, 2.33, N, 0.03.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06110962
출처 데이터셋	uspto-grants-2000_08
ORD ID	ord-a1a8cd6a36ee4797b0214ca1c11e53cc
출처 메모	uspto-grants-2000_08