Bromine → (2R)-2-[2,6-Dibromo-4-(6-bromo-benzo[b]naphtho[2,3-d]thiophen-11-yl)-phenoxy]-4-(1-oxo-1,3-dihydro-isoindol-2-yl)-butyric acid

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Reaction Steps

Prepared from of 2,6-dibromo-4-(6-bromo-benzo[b]naphtho[2,3-d]thiophen-1 1-yl)-phenol (Example 21) and (S)-(+)-α-hydroxy-1-oxo-2-isoindolinebutyric acid methyl ester (Example 106). White solid: mp 239-241° C.: NMR (CDCl3); δ8.34 (d, J =8 Hz, 1 H), 7.90 (d, J=8 Hz, 1 H), 7.80 (d, J=8 Hz, 1 H), 7.66 (ddd, J=8, 7, 1 Hz, 1 H), 7.62-7.58 (m, 4 H), 7.52-7.47 (m, 3 H), 7.39 (ddd, J=8, 7, 1 Hz, 1 H), 7.14 (ddd, J =8, 7, 1 Hz, 1 H), 6.72 (d, J=8, Hz, 1 H), 5.39 (t, J=7 Hz, 1 H), 4.59 (m, 2 H), 4.22-3.93 (m, 2 H), 2.65 (t, J=6 Hz, 2 H); MS (+FAB): [M+H]+, 3 bromine isotope pattern, 778, 780, 782, 784); Anal. Calc. for C34H22Br3NO4S: C, 52.33, H, 2.84, N, 1.79. Found: C, 52.11, H, 2.73, N, 1.79.

Provenance & Evidence