Bromine → HCID 9939918, compound

Participants

Reaction Steps

Prepared from of 2,6-dibromo-4-(6-trifluoromethyl-benzo[b]naphtho[2,3-d ]thiophen-11-yl)-phenol (Example 61) and (S)-2-hydroxy-3-phenylpropionic acid, methyl ester (Example 96). White solid: mp 109-143° C.; [a]D25=+47.99° (10.002 mg/mL CH3OH); NMR (DMSO-d6); δ13.26 (s, 1 H), 8.30 - 8.27 (m, 1 H), 8.06 (d, J =7 Hz, 1 H), 7.87 - 7.81 (m, 3 H), 7.71 - 7.60 (m, 2 H), 7.52 (dd, J=8, 1 Hz, 1 H), 7.43 -7.24 (m, 6 H), 6.60 (d, J=8 Hz, 1 H), 5.33 (t, J=7 Hz, 1 H), 3.41 (d, J=7 Hz, 2 H); MS (EI): [M+], 2 bromine isotope pattern, 698 (8%), 700 (20%) 702 (15%); Anal. Calc. for C32H19Br2F3O3S: C, 54.88, H, 2.74, N, 0.00. Found: C, 55.29, H, 3.11, N, 0.10.

Provenance & Evidence