Bromine → HCID 21970365, compound

Participants

Reaction Steps

Prepared from of 2,6-dibromo-4-[6-(2-dimethylamino-ethylsulfanyl)-benzo [b]naphtho[2,3-d]thiophen-11-yl]-phenol (Example 66) and (S)-2-hydroxy-3-phenylpropionic acid, methyl ester (Example 96). White solid: mp 169-174° C.; NMR (DMSO-d6); δ13.3 (broad s, 1 H), 8.64 (d, J=8 Hz, 1 H), 8.04 (d, J=8 Hz, 1 H), 7.81 (ddd, J=8,7,1 Hz, 1 H), 7.76 (dd, J=16,1 Hz), 7.72-7.48 (m, 4 H), 7.42-7.22 (m, 7 H), 6.64 (d, J=8 Hz, 1 H), 5.32 (t, J=7 Hz, 1 H), 3.36-3.14 (m, 6 H); 2.64 (s, 6 H); MS (+FAB): [(M+H)+], 2 bromine isotope pattern, 734-(55%), 736 (100%), 738 (70%). Anal. calc. for C35H29Br2NO3S2; C, 54.45, H, 3.92, N, 1.81. Found: C, 54.46, H, 3.76, N, 1.66.

Provenance & Evidence