Bromine → HCID 9896243, compound

Participants

Reaction Steps

Prepared from of 2,6-dibromo-4-(6-iodo-benzo[b]naphtho[2,3-d]thiophen-11-yl )-phenol (Example 59) and commercially available (S)-lactic acid, methyl ester. White solid: mp 129-196° C. dec; Opt. rot. [a]25/D=+4.312° (8.812 mg/mL, CHCl3); NMR (DMSO-d6); δ13.12 (broad s, 1 H), 8.12 (d, J=8, 1 Hz, 1 H), 8.06 (d, J =7 Hz, 1 H), 7.82 (q, J=Hz, 2 H), 7.75 (ddd, J=8,7, 1 Hz, 1 H), 7.62-7.49 (m, 3 H), 7.27 (ddd, J=8, 7, 1 Hz, 1 H), 6.61 (d, J=8 Hz, 1 H), 5.12 (q, J=7 Hz, 1 H), 1.63 (d, J =7 Hz, 3 H); MS (+FAB): [M+], 2 bromine isotope pattern, 680 (45%), 682 (100%), 684 (60%); Anal. Calc. for C25H15Br2IO3S: C, 44.02, H, 2.22, N, 0.00; Found: C, 44.66, H, 2.54, N, 0.21.

Provenance & Evidence