methyl (2S)-2-hydroxy-2-phenylacetate → HCID 53965114, compound

HRID 1873183Notes

Reaction equation

HRID 1873183 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([C:8]2[C:17]3[C:18]4[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=4[S:20][C:16]=3[C:15]([Br:25])=[C:14]3[C:9]=2[CH:10]=[CH:11][CH:12]=[CH:13]3)[CH:5]=[C:4]([Br:26])[C:3]=1[OH:27].[C:28]([O:38]C)(=[O:37])[C@H:29]([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)O>>[Br:26][C:4]1[CH:5]=[C:6]([C:8]2[C:17]3[C:18]4[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=4[S:20][C:16]=3[C:15]([Br:25])=[C:14]3[C:9]=2[CH:10]=[CH:11][CH:12]=[CH:13]3)[CH:7]=[C:2]([Br:1])[C:3]=1[O:27][C@H:29]([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[C:28]([OH:38])=[O:37]

Participants

3

Reactant 2

HCID 643570methyl (2S)-2-hydroxy-2-phenylacetateHCID 108406542,6-Dibromo-4-(6-bromo-benzo[b]naphtho[2,3-d]thiophen-11-yl)-phenol

Product 1

HCID 53965114HCID 53965114, compound

Procedure

Prepared from 2,6-dibromo-4-(6-bromo-benzo[b]naphtho [2,3-d]thiophen-11 -yl)-phenol (Example 21) and commercially avialable methly (s)-(+)-mandelate. White solid: mp 135-137° C.: MS (FAB-): [M-H]-, 693; Anal. Calc. for C3OH17Br3O3S: C, 51.68, H, 2.46, N, 0.00. Found: C 51.57, H, 2.89, N, 0.14.

Sources & evidence

ORD record
ord-90776a12b3e14182844cd09f13335ede
Source dataset
uspto-grants-2000_08
Patent number
US06110962

Reaction notes

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