2,4-Dimethoxybenzoyl chloride → HCID 18687870, compound

HRID 1873218Notes

Reaction equation

HRID 1873218 reaction equation
[CH2:1]([C:8]1[O:9][C:10]2[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=2[CH:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:17][O:18][C:19]1[CH:27]=[C:26]([O:28][CH3:29])[CH:25]=[CH:24][C:20]=1[C:21](Cl)=[O:22]>>[CH2:1]([C:8]1[O:9][C:10]2[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=2[C:12]=1[C:21]([C:20]1[CH:24]=[CH:25][C:26]([O:28][CH3:29])=[CH:27][C:19]=1[O:18][CH3:17])=[O:22])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 27347192,4-Dimethoxybenzoyl chlorideHCID 12218409HCID 12218409, compound

Product 1

HCID 18687870HCID 18687870, compound

Procedure

Prepared from 2-benzyl-benzofuran and 2, 4-dimethoxybenzoyl chloride according to the procedure in Example 207. White solid (6.88g): mp 74-76C.; NMR (CDCl3); δ7.47(d, J=8Hz, 1 H), 7.40 (dd, J=2,1 Hz, 1 H), 7.31 - 7.24 (m, 5 H), 7.24 -7.19 (m, 2 H), 7.16 - 7.12 (m, 1 H), 6.55 (d, J=2, Hz, 1 H), 6.48 (s, 1 H), 4.29 (s, 2 H), 3.89 (s, 3 H), 3.58 (s, 3 H), MS (EI): [M*+m/z] 372(55%), 165(100%), 234(88%), Anal. Calc. for C24H20O4, C,77.40, H, 5.41, N, 0.00. Found: C, 77.48, H, 5.44, N, 0.09.

Sources & evidence

ORD record
ord-284beedb524043238d8aadd7f93fa9ea
Source dataset
uspto-grants-2000_08
Patent number
US06110962

Reaction notes

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