2-Mercaptobenzoic Acid → HCID 15480017, compound

Participants

Reaction Steps

Preparation-III of the invention for preparing Zaltoprofen is characterized in that 2-(4-amino-3-carboxymethylphenyl)propionic acid or its salt is diazotized and then reacted with thiosalicylic acid to give 2-[3-carboxymethyl-4-(2-carboxyphenylthio)phenyl]propionic acid or its salt; the resulting compound is esterified to give 2-[3-(lower)alkoxycarbonylmethyl-4-(2-(lower)alkoxycarbonylphenylthio)phenyl]propionic acid (lower)alkyl ester; the resulting ester is subjected to cyclization reaction, to give 2-(10,11-dihydro-11-(lower)alkoxycarbonyl-10-oxodibenzo[b,f]thiepin-2-yl)propionic acid (lower)alkyl ester; and the resulting ester is finally subjected to hydrolysis and decarboxylation. Preparation-III is illustrated in the following reaction scheme III: ##STR9## 1) Preparation of 2-[3-carboxymethyl-4-(2-carboxyphenylthio)phenyl]propionic acid or its salt

Provenance & Evidence