反应详情

In 1N aqueous sodium hydroxide solution (6 mL) was dissolved 2-(3-carboxymethyl-4-nitrophenyl)propionic acid (obtained in Example 1, 760 mg, 3 mmol.). The solution was stirred for 18 hours at room temperature in a hydrogen gas atmosphere, after addition of 1006 palladium/carbon (15 mg). Insolubles were removed by filtration, and the filtrate was concentrated under reduced pressure to give a brown crystalline product. The obtained crystalline product was washed successively with ethanol and hexane to give 734 mg (yield: 91.7%) of the desired compound as a white crystalline product.

1. customInsolubles were removed by filtration
2. concentrationthe filtrate was concentrated under reduced pressure
3. customto give a brown crystalline product
4. washThe obtained crystalline product was washed successively with ethanol and hexane