Zaltoprofen → HCID 9883399, compound

HRID 1873238Notes

Reaction equation

[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[S:6][C:5]2[CH:13]=[CH:14][C:15]([CH:17]([CH3:21])[C:18]([OH:20])=[O:19])=[CH:16][C:4]=2[CH2:3]1.NC1C=CC(C(C)C(O)=[O:31])=CC=1CC(O)=O.C1(S)C=CC=CC=1>>[C:2]([CH2:3][C:4]1[CH:16]=[C:15]([CH:17]([CH3:21])[C:18]([OH:20])=[O:19])[CH:14]=[CH:13][C:5]=1[S:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)([OH:1])=[O:31]

Participants

Reactant 3

HCID 5720Zaltoprofen

HCID 7969Thiophenol

HCID 11138738HCID 11138738, compound

Product 1

HCID 9883399HCID 9883399, compound

Procedure

A process for preparing 2-(10,11-dihydro-10-oxodibenzo [b,f] thiepin-2-yl)propionic acid which comprises subjecting 2-(4-amino-3-carboxymethylphenyl)propionic acid or its salt to diazotization and subsequent reaction with thiophenol to produce 2-(3-carboxymethyl-4-phenylthiophenyl)propionic acid or its salt, and subjecting the product to cyclization reaction.

Sources & evidence

ORD record: ord-0f8d9e2b8ffc45ce9968896a5029ea0b
Source dataset: uspto-grants-2000_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06111115

Reaction notes

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