2-Mercaptobenzoic Acid → HCID 15480017, compound

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Reaction Steps

A process for preparing 2-(10,11-dihydro-10-oxodibenzo [b,f] thiepin-2-yl)propionic acid which comprises subjecting 2-(4-amino-3-carboxymethylphenyl)propionic acid or its salt to diazotization and subsequent reaction with thiosalicylic acid to produce 2-[3-carboxymethyl-4-(2-carboxyphenylthio)phenyl]propionic acid or its salt, esterifying the product to give a 2-[3-(lower)alkoxycarbonylmethyl-4-(2-(lower)alkoxycarbonylphenylthio)phenyl]-propionic acid (lower)alkyl ester, cyclizing the resulting ester to produce a 2-(10,11-dihydro-11-(lower)alkoxycarbonyl-10-oxodibenzo [b,f] thiepin-2-yl)propionic acid (lower)alkyl ester, and subjecting the resulting ester to hydrolysis and decarboxylation.

Provenance & Evidence