HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → HCID 178455987, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 2,5,6,10,13-Pentaazatetradecanedioic acid, 12-(1,1-dimethylethyl)-8-hydroxy-6-((4-(2-(1-methyl-1-phenylethyl)-2H-tetrazol-5-yl)phenyl)methyl)-3-(1-methylpropyl)-4,11-dioxo-9-(phenylmethyl)-, dimethyl ester,(3S-(3R*(R*),8R*,9R*,12R*))- | HCID 467973 | — |
| Product | HCID 178455987 | HCID 178455987 | — |
Reaction Steps
35 ml of an 80% aqueous H2SO4 solution are added to 354 mg (0.435 mmol) of 1-{4-[2-(1-methyl-1-phenyl-ethyl)-2H-tetrazol-5-yl]-phenyl}-4(S)-hydroxy-2-N-(N-methoxycarbonyl-(L)-iso-leucyl)amino-5(S)-N-(N-methoxycarbonyl-(L)-tert-leucyl)amino-6-phenyl-2-azahexane, with ice-cooling. After stirring for 75 min, the mixture is worked up analogously to Example 26 to yield the title compound: HPLC20-100 : tRet =12.6; FAB MS (M+H)+ =696.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06110946 |
| Source dataset | uspto-grants-2000_08 |
| ORD ID | ord-e37f6b1a90334aca80874ec600adfbb7 |
| Source note | uspto-grants-2000_08 |