Sulfuric Acid → HCID 178455986, compound

HRID 1873281Notes

Reaction equation

HRID 1873281 reaction equation
CC([N:10]1[N:14]=[N:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([CH2:21][N:22]([NH:47][C:48](=[O:59])[C@H:49]([C:55]([CH3:58])([CH3:57])[CH3:56])[NH:50][C:51]([O:53][CH3:54])=[O:52])[CH2:23][C@H:24]([OH:46])[C@@H:25]([NH:33][C:34](=[O:45])[C@H:35]([C@H:41]([CH2:43][CH3:44])[CH3:42])[NH:36][C:37]([O:39][CH3:40])=[O:38])[CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[CH:17][CH:16]=2)=[N:11]1)(C1C=CC=CC=1)C.S(=O)(=O)(O)O>>[NH:13]1[C:12]([C:15]2[CH:16]=[CH:17][C:18]([CH2:21][N:22]([NH:47][C:48](=[O:59])[C@H:49]([C:55]([CH3:56])([CH3:58])[CH3:57])[NH:50][C:51]([O:53][CH3:54])=[O:52])[CH2:23][C@H:24]([OH:46])[C@@H:25]([NH:33][C:34](=[O:45])[C@H:35]([C@H:41]([CH2:43][CH3:44])[CH3:42])[NH:36][C:37]([O:39][CH3:40])=[O:38])[CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[CH:19][CH:20]=2)=[N:11][N:10]=[N:14]1

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 4679761-(4-(2-(1-Methyl-1-phenyl-ethyl)-2H-tetrazol-5-yl)-phenyl)-4(S)-hydroxy-2-N-(N-methoxycarbonyl-(L)-tert-leucyl)amino)-5(S)-N-(N-methoxycarbonyl-(L)-iso-leucyl)amino-6-phenyl-2-azahexane

Product 1

HCID 178455986HCID 178455986, compound

Procedure

Analogously to Example 26, 1-{4-[2-(1-methyl-1-phenyl-ethyl)-2H-tetrazol-5-yl]-phenyl}-4(S)-hydroxy-2-N-(N-methoxycarbonyl-(L)-tert-leucyl)amino-5(S)-N-(N-methoxycarbonyl-(L)-iso-leucyl)amino-6-phenyl-2-azahexane is deprotected with 80% sulfuric acid to form the title compound.

Sources & evidence

ORD record
ord-82fb85a1721d426c83ea8ecfdcebe29d
Source dataset
uspto-grants-2000_08
Patent number
US06110946

Reaction notes

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