Hydrochloric Acid → HCID 66578350, compound

Participants

Reaction Steps

Analogously to Example 37f), 130 ml of 4 M HCl in dioxane are added to 4.4 g (6.94 mmol) of 1-[4-(pyridin-2-yl)-phenyl]-4(S)-hydroxy-2-N-Boc-amino-5(S)-N-(N-methoxycarbonyl-(L)-tert-leucyl)amino-6-phenyl-2-azahexane and the mixture is diluted with 7 ml of DMF. After 2.75 hours, the mixture is worked up. The title compound is obtained: TLC: Rf =0.44 (methylene chloride/methanol: 9/1); HPLC20-100 : tRet =8.47; FAB MS (M+H)+ =534.

Provenance & Evidence