HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propargyl bromide → 1,2-Difluoro-3-prop-2-ynyloxybenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propargyl bromide | HCID 7842 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2,3-Difluorophenol | HCID 80879 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 1,2-Difluoro-3-prop-2-ynyloxybenzene | HCID 59215238 | — |
Reaction Steps
115.0 g (0.88 mol) of 2,3-difluorophenol are refluxed for 3 h in 1.6 l of ethyl methyl ketone together with 118.2 ml (17.7 mol) of propargyl bromide (80% soln. in toluene) and 146.6 g (138.2 mol) of potassium carbonate. The batch is filtered, and the filter residue is washed with MTBE. The filtrate is evaporated to dryness, and the residue is purified by column chromatography (SiO2, n-heptane:MTBE=3:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08303844B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-1534a6585e12484da63b7f5d73c818ae |
| Source note | uspto-grants-2012_11 |