Hydrochloric Acid → HCID 178502825、化合物

HRID 1873342ノート

反応式

HRID 1873342 の反応式
[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:9])[NH2:8].[CH3:13][N:14]1[N:20]=[C:19]([OH:21])[C:17](=[O:18])[N:16]=[C:15]1[S:22][CH2:23][C:24]1[CH2:45][S:44][C@@H:27]2[C@H:28]([NH:31][C:32](/[C:34](/[C:38]3[N:42]=[C:41]([NH2:43])[S:40][CH:39]=3)=[N:35]\[O:36][CH3:37])=[O:33])[C:29](=[O:30])[N:26]2[C:25]=1[C:46]([OH:48])=[O:47].Cl>O>[CH3:13][N:14]1[N:20]=[C:19]([OH:21])[C:17](=[O:18])[N:16]=[C:15]1[S:22][CH2:23][C:24]1[CH2:45][S:44][C@@H:27]2[C@H:28]([NH:31][C:32](/[C:34](/[C:38]3[N:42]=[C:41]([NH2:43])[S:40][CH:39]=3)=[N:35]\[O:36][CH3:37])=[O:33])[C:29](=[O:30])[N:26]2[C:25]=1[C:46]([OH:48])=[O:47].[NH2:1][C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:8])[NH2:9]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 178418600HCID 178418600、化合物3 回HCID 178502822HCID 178502822、化合物2 回

生成物 1

HCID 178502825HCID 178502825、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

About 582 mg (3.34 mole) of arginine was dissolved in 50 ml of distilled water. Additionally, about 1.0 grams (1.67 mole) of ceftriaxone was dissolved in 50 ml of a separate volume of distilled water. The solution containing arginine was adjusted with 1N—HCl until the pH reached 6.0. The ceftriaxone solution was then added to the arginine solution and mixed by a magnetic stirrer at room temperature for 1 hour forming a ceftriaxone-arginine solution. To the ceftriaxone-arginine solution was added about 400 mg of carrageenan and the solution was mixed by magnetic stirrer at room temperature for 2 hours. A ceftriaxone-arginine-carrageenan complex was formed which was freeze-dried while in the swollen state, yielding about 1.84 g of the freeze dried complex.

後処理

  1. additionmixed by a magnetic stirrer at room temperature for 1 hour

出典と根拠

ORDレコード
ord-5301b916baae4aea84ecd258cf2ae490
出典データセット
uspto-grants-2012_11
特許番号
US08303989B2

反応ノート

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