反应详情

3.0 g (5.0 mmol) of 2-(2′,3′-difluoro-4′-propoxybiphenyl-4-yl)-5-vinylselenophene are hydrogenated in 90 ml of ethyl acetate/toluene (2:1), in the presence of Pd/C (5% of Pd) at atmospheric pressure and RT. The reaction soln. is filtered and concentrated to dryness. The crude product is purified by column chromatography (SiO2, n-heptane:toluene=2:1). The further purification is carried out by recrystallisation from n-heptane. 2-(2′,3′-Difluoro-4′-propoxybiphenyl-4-yl)-5-ethylselenophene is obtained as a solid having an m.p. of 126° C.

1. filtrationis filtered
2. concentrationconcentrated to dryness
3. customThe crude product is purified by column chromatography (SiO2, n-heptane:toluene=2:1)
4. customThe further purification
5. customis carried out by recrystallisation from n-heptane