Acetic Anhydride → N-{2-bromo-4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]benzyl}acetamide

Participants

Role	Name	HCID	Charge
Reactant	Acetic Anhydride	HCID 7918	—
Reactant	2-(4-aminomethyl-3-bromophenyl)-4-(3,5-dichlorophenyl)-4-trifluoromethyl-4,5-dihydro-3H-pyrrole	HCID 58092109	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	N-{2-bromo-4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]benzyl}acetamide	HCID 44183261	61.2%

Reaction Steps

To a solution of 1-(2-bromo-4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]phenyl)methanamine (0.15 g) in THF (10 ml) was added acetic anhydride (0.04 g), and the mixture was stirred for 1 hour at room temperature. The mixture was concentrated under reduced pressure to give residual material which was purified by silica gel chromatography, to obtain N-{2-bromo-4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]benzyl}acetamide (0.1 g).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08304371B2
Source dataset	uspto-grants-2012_11
ORD ID	ord-b45bd45126db49e883eca973af04bd11
Source note	uspto-grants-2012_11