Pentafluoropropionic acid → Propanoic acid, 2,2,3,3,3-pentafluoro-, potassium salt (1:1)

HRID 1873492Notes

Reaction equation

HRID 1873492 reaction equation
[F:1][C:2]([F:10])([F:9])[C:3]([F:8])([F:7])[C:4]([OH:6])=[O:5].CC([O-])(C)C.[K+:16]>CCOCC>[F:7][C:3]([F:8])([C:2]([F:10])([F:9])[F:1])[C:4]([O-:6])=[O:5].[K+:16]

Participants

4

Reactant 2

HCID 62356Pentafluoropropionic acidHCID 23665647Potassium tert-butoxide

Product 1

HCID 23667659Propanoic acid, 2,2,3,3,3-pentafluoro-, potassium salt (1:1)

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Pentafluoropropionic acid (20.5 g, 183 mmol) was slowly added to a solution of KOtBu (29.9 g, 183 mmol) in ether (400 mL) at 0° C. After 30 minutes the ice bath was removed. After stirring at room temperature for 4 hours the suspension was filtered and the cake was washed with ether (200 mL). The fine white solid was placed under vacuum for 16 hours prior to use.

Workup

  1. customAfter 30 minutes the ice bath was removed
  2. filtrationwas filtered
  3. washthe cake was washed with ether (200 mL)
  4. waitThe fine white solid was placed under vacuum for 16 hours

Sources & evidence

ORD record
ord-39ea8b2500c24069af72035c86d46a2f
Source dataset
uspto-grants-2012_11
Patent number
US08304407B2

Reaction notes

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