2,3-Dihydroxybutanedioic Acid → 5-[2-((2S,4S)-2-cyano-4-fluoro-pyrrolidin-1-yl)-2-oxo-ethylamino]-N,N,5-trimethyl-hexahydro-cyclopenta[c]pyrrole-2-carboxamide tartrate

Participants

Reaction Steps

5-[2-((2S,4S)-2-Cyano-4-fluoro-pyrrolidin-1-yl)-2-oxo-ethylamino]-N,N,5-trimethyl-hexahydro-cyclopenta[c]pyrrole-2(1H)-2-carboxamide 13h (0.16 g, 0.44 mmol) was dissolved in 5 mL of dichloromethane with stirring followed by dropwise addition of a solution of 5 mL of tartaric acid (65.6 mg, 0.44 mmol) in acetone. The reaction mixture was reacted for 30 minutes resulting in the formation of a white precipitate. The mixture was filtered and the filter cake was washed with acetone to obtain the title compound 5-[2-((2S,4S)-2-cyano-4-fluoro-pyrrolidin-1-yl)-2-oxo-ethylamino]-N,N,5-trimethyl-hexahydro-cyclopenta[c]pyrrole-2-carboxamide tartrate 13 (0.18 g, yield 82%) as a white solid.

Provenance & Evidence