2,3-Dihydroxybutanedioic Acid → HCID 68775040, compound

Participants

Reaction Steps

5-Cyclopentyl-5-[2-((S)-2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid dimethylamide 16g (102 mg, 0.254 mmol) was dissolved in 2 mL of ethyl acetate followed by addition of a solution of 3 mL of tartaric acid in acetone. The reaction mixture was stirred for 30 minutes resulting in the formation of a white precipitate followed by addition of n-hexane, and stirred again. The mixture was filtered to obtain the title compound 5-cyclopentyl-5-[2-((S)-2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid dimethylamide tartrate 16 (88 mg, yield 65%) as a white solid.

Provenance & Evidence