Methanol → HCID 59161040, compound

HRID 1873556Notes

Reaction equation

HRID 1873556 reaction equation
[OH:1][CH2:2][CH2:3][O:4][CH:5]1[CH2:10][CH2:9][CH:8]([C:11]([OH:13])=[O:12])[CH2:7][CH2:6]1.[CH3:14]O>>[OH:1][CH2:2][CH2:3][O:4][CH:5]1[CH2:10][CH2:9][CH:8]([C:11]([O:13][CH3:14])=[O:12])[CH2:7][CH2:6]1

Participants

3

Reactant 2

HCID 887MethanolHCID 59160967HCID 59160967, compound

Product 1

HCID 59161040HCID 59161040, compound

Procedure

The crude product from Example 1A is dissolved in 40 ml of methanol, and 200 mg of Dowex 50 WX8-100 ion exchanger (washed beforehand 7× with in each case 20 ml of 2 M hydrochloric acid and then 7× with in each case 20 ml of methanol) are added. The mixture is stirred at +64° C. for 20 h. After cooling to RT, the ion exchanger is filtered off and the filtrate is concentrated on a rotary evaporator. The crude product is directly used in the next reaction without further purification.

Workup

  1. wash200 mg of Dowex 50 WX8-100 ion exchanger (washed beforehand 7× with in each case 20 ml of 2 M hydrochloric acid
  2. addition7× with in each case 20 ml of methanol) are added
  3. filtrationthe ion exchanger is filtered off
  4. concentrationthe filtrate is concentrated on a rotary evaporator
  5. customThe crude product is directly used in the next reaction without further purification

Sources & evidence

ORD record
ord-0b93d84a4f294015a2ab2ef1e32f2850
Source dataset
uspto-grants-2012_11
Patent number
US08304412B2

Reaction notes

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