Sulfuric Acid → Methyl 4-hydroxycyclohexanecarboxylate

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Reaction Steps

5.00 g (34.68 mmol) of 4-hydroxycyclohexanecarboxylic acid are dissolved in 80 ml of methanol, and 2 ml of conc. sulfuric acid are added slowly. The mixture is stirred under reflux for 20 h. After cooling to RT, the mixture is carefully poured into a mixture of 100 ml of ethyl acetate and 100 ml of saturated aqueous sodium bicarbonate solution. The phases are separated, and the organic phase is washed once with 20 ml of saturated aqueous ammonium chloride solution. The organic phase is dried over magnesium sulfate and the solvent is removed on a rotary evaporator. The crude product is directly used in the next reaction without further purification.

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