Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Bicarbonate → HCID 178455311, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | Hydrogen chloride dimer | HCID 6410751 | — |
| 반응물 | 2-Amino-4-(4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-6-mercaptopyridine-3,5-dicarbonitrile | HCID 178455031 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 178455311 | HCID 178455311 | — |
반응 단계
97 mg (0.23 mmol) of the compound from Example 12A (cis isomer), 46 mg (0.28 mmol) of 3-pyridinemethyl chloride hydrochloride and 78 mg (0.93 mmol) of sodium bicarbonate are initially charged in 2 ml of dry DMF and stirred at RT for 20 h. The mixture is then filtered and the filtrate is directly purified by preparative HPLC (column: YMC GEL ODS-AQ S-5/15 μm; mobile phase gradient: acetonitrile/water 10:90→95:5).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08304412B2 |
| 출처 데이터셋 | uspto-grants-2012_11 |
| ORD ID | ord-d4aef8cd923d4cbea1d0936d25f682a3 |
| 출처 메모 | uspto-grants-2012_11 |