Methyl morpholine oxide → HCID 59160962, compound

Participants

Reaction Steps

600 mg (2.79 mmol) of the compound from Example 22A are dissolved in 6 ml of dry dichloromethane, and 1.5 g of powdered molecular sieve (4 Å) and 490 mg (4.18 mmol) of N-methylmorpholine N-oxide are added. 49 mg (0.14 mmol) of tetrapropylammonium perruthenate are then added, and the mixture is stirred at RT for 1 h. The reaction mixture is then directly purified chromatographically on silica gel 60 (mobile phase: gradient dichloromethane/ethanol 100:1→20:1).

Provenance & Evidence